Cancer Alternative – Change Frequency of Your Treatment for more Effective Results
March 30, 2010
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Posted by admin
I read articles daily about health, wealth and prosperity. The books I read books are primarily about various aspects of prosperity; however, on occasion, I find something I want to read about some aspect of health, nutrition, fitness, supplements or alternative medicine. I consider my best source of health information to be the Life Extension magazine, a monthly publication. I was somewhat surprised to find a very interesting article in the March 15, 2010 Forbes magazine. There is an article on page 18, Terrorist Cells – Larry Norton is pushing a radical new theory of how cancer spreads – and how to cure it, by Robert Langreth.
Larry Norton is applying mathematics to the spread of cancer – using differential equations to describe the rate that tumors grow. His approach came from frequent observations that a large tumor would shrink rapidly during chemo treatment, and would grow again rapidly in multiple locations. In December’s issue of Life Extension, there is a great article on metastasis and what you can do to slow down or prevent cancer cells from metastasizing. I’ll write a blog on that article shortly. In the most recent issue of Life Extension, there are two articles discussing circulating tumor cells and what a new technology has learned about traditional cancer treatments. I’ll also write a blog about those two articles shortly.
Getting back to Larry Norton and his quest to apply mathematics to curing cancer, he discovered that changing the frequency of chemo treatments can be extremely valuable in boosting the effectiveness of the chemo therapy. The traditional belief is that the tumor cell grows from the inside out. Sloan-Kettering biologist Joan Massague is postulating that tumors grow like weeds – they constantly produce seeds that enter your blood stream and get deposited in other places in your body; or, they return to the mother ship and give the primary tumor more momentum to grow again. The original tumor started in a particular place for a reason – the returning cancer seeds can re-germinate in the original tumor location, even after that primary tumor has been removed – that explains why tumors come back in the same place that they were removed. He also states that we will most likely see a new family of drugs specifically designed to attack the circulating cancer cells.
Larry Norton was a Fellow at the National Cancer Institute in the 70’s and has been trying to describe the mathematics behind typical and atypical cancer growth. In some patients the predictions were very accurate – in others, they were way off base. Based on those unusual growth spurts, Norton hypothesized a new theory based on the 19th century mathematician, Benjamin Gompertz. This new theory states that the growth of some cancer cells is based on an S-shaped curve. Small, almost undetectable cancer cells grow very slowly, or almost not at all. As they get just a little bigger, they begin a new life – they grow at the expected exponential rate until they achieve an optimum size. At this point in time they slow down again in their growth phase. Based on this model, the faster you shrink a tumor with chemo, the faster the potential for it to grow back, since the size of the cancer cell dictates the growth rate. If you didn’t kill the primary tumor quickly enough, it can recover and regenerate.
Norton speculated that if the same overall amount of chemo was given over shorter periods of time, the likelihood of effectiveness would increase. He has had lots of difficulty with the established cancer treatment community in believing this or wanting to test it. It took Norton decades to perfect his theory and finally in 2002, the government undertook a study to test the frequency of chemo versus the results. The outcome proved his theory – giving chemo every two weeks instead of every three weeks made the chemo more effective. The two-week group post treatment showed a 26% reduction in cancer recurrence after three years compared to the standard three-week chemo group. Today, the two-week dosage has become standard with certain high-risk cancer patients.
Norton pressed on with his research and found some interesting facts – the cancer cells, or seeds, that travel through the blood stream are traditionally thought to be fast dividing and replicating cells. His research has discovered that the metastasizing cells are actually normal cancer cells that had adapted to new environments. This disproves to an extent that fast growing tumors are most likely to spread. Additionally, his seeding theory has been supported to a degree with the growth rates of different sized tumors. Large tumors may be restricted in their ability to grow at the same rate as smaller tumors because of their surface area. The cancer seeds released may be part of the growth cycle to help the large tumor continue growing by providing additional growth sites on the primary tumor. Growth of a tumor seems to be based more of surface area than volume. It may be that tumors that release a lot of cancer seeds may be more virulent killers because of this mechanism compared to the previously their thought faster growth rate.
Standby for additional updates on this general theme in the next few blogs.
Choices have consequences. Your Prosperity Professor, Red O’Laughlin
Categories: cancer
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Tags: blood stream, cancer, chemo, circulating tumor cells, CTC, differential equations, Forbes, Health, Life Extension magazine, mathematics, metastasis, treatments, tumors
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